| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TOMM70 |
| Gene ID: | 9868 |
| Uniprot ID: | TOM70_HUMAN |
| Immunogen Region: | 245-608 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 245-608 of human TOM70 (NP_055635.3). |
| Immunogen Sequence: | KNREPLMPSPQFIKSYFSSF TDDIISQPMLKGEKSDEDKD KEGEALEVKENSGYLKAKQY MEEENYDKIISECSKEIDAE GKYMAEALLLRATFYLLIGN ANAAKPDLDKVISLKEANVK LRANALIKRGSMYMQQQQPL LSTQDFNMAADIDPQNADVY HHRGQLKILLDQVEEAVADF DECIRLRPESALAQAQKCFA LYRQAYTGNNSSQIQAAMKG FEEVIKKFPRCAEGYALYA |
| Function | Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner. Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection. Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis. |
| Protein Name | Mitochondrial Import Receptor Subunit Tom70 Mitochondrial Precursor Proteins Import Receptor Translocase Of Outer Membrane 70 Kda Subunit Translocase Of Outer Mitochondrial Membrane Protein 70 |
| Database Links | Reactome: R-HSA-1268020 Reactome: R-HSA-168928 Reactome: R-HSA-5205685 Reactome: R-HSA-5689880 Reactome: R-HSA-9692916 Reactome: R-HSA-9705671 |
| Cellular Localisation | Mitochondrion Outer Membrane Single-Pass Membrane Protein (Microbial Infection) During Parasite T Gondii-Mediated Infection Enriched At The Interface Between The Host Mitochondria And The Parasitopharous Vacuole |
| Alternative Antibody Names | Anti-Mitochondrial Import Receptor Subunit Tom70 antibody Anti-Mitochondrial Precursor Proteins Import Receptor antibody Anti-Translocase Of Outer Membrane 70 Kda Subunit antibody Anti-Translocase Of Outer Mitochondrial Membrane Protein 70 antibody Anti-TOMM70 antibody Anti-KIAA0719 antibody Anti-TOM70 antibody Anti-TOMM70A antibody |
Information sourced from Uniprot.org