| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Non-Receptor Tyrosine-Protein Kinase Tnk1 (100-380) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TNK1 |
| Gene ID: |
8711 |
| Uniprot ID: |
TNK1_HUMAN |
| Immunogen Region: |
100-380 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 100-380 of human TNK1 (NP_001238831.1). |
| Immunogen Sequence: |
LPEPEGGLKCLIPEGAVCRG ELLGSGCFGVVHRGLWTLPS GKSVPVAVKSLRVGPEGPMG TELGDFLREVSVMMNLEHPH VLRLHGLVLGQPLQMVMELA PLGSLHARLTAPAPTPPLLV ALLCLFLRQLAGAMAYLGAR GLVHRDLATRNLLLASPRTI KVADFGLVRPLGGARGRYVM GGPRPIPYAWCAPESLRHGA FSSASDVWMFGVTLWEMFSG GEEPWAGVPPYLILQRLED |
| Tissue Specificity | Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain. |
| Post Translational Modifications | Autophosphorylated on tyrosine residues. |
| Function | Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. |
| Protein Name | Non-Receptor Tyrosine-Protein Kinase Tnk1Cd38 Negative Kinase 1 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Non-Receptor Tyrosine-Protein Kinase Tnk1 antibodyAnti-Cd38 Negative Kinase 1 antibodyAnti-TNK1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
