• Western blot analysis of extracts of T-47D cells, using TNK1 antibody (STJ11104270) at 1:600 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.

Anti-TNK1 antibody (100-380) (STJ11104270)

SKU:
STJ11104270

$151.88 - $705.38
Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Non-Receptor Tyrosine-Protein Kinase Tnk1 (100-380) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TNK1
Gene ID: 8711
Uniprot ID: TNK1_HUMAN
Immunogen Region: 100-380
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 100-380 of human TNK1 (NP_001238831.1).
Immunogen Sequence: LPEPEGGLKCLIPEGAVCRG ELLGSGCFGVVHRGLWTLPS GKSVPVAVKSLRVGPEGPMG TELGDFLREVSVMMNLEHPH VLRLHGLVLGQPLQMVMELA PLGSLHARLTAPAPTPPLLV ALLCLFLRQLAGAMAYLGAR GLVHRDLATRNLLLASPRTI KVADFGLVRPLGGARGRYVM GGPRPIPYAWCAPESLRHGA FSSASDVWMFGVTLWEMFSG GEEPWAGVPPYLILQRLED
Tissue Specificity Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain.
Post Translational Modifications Autophosphorylated on tyrosine residues.
Function Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.
Protein Name Non-Receptor Tyrosine-Protein Kinase Tnk1
Cd38 Negative Kinase 1
Cellular Localisation Cytoplasm
Membrane
Peripheral Membrane Protein
Alternative Antibody Names Anti-Non-Receptor Tyrosine-Protein Kinase Tnk1 antibody
Anti-Cd38 Negative Kinase 1 antibody
Anti-TNK1 antibody

Information sourced from Uniprot.org

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