| Host: |
Rabbit |
| Applications: |
WB/IHC/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Tnfaip3-Interacting Protein 1 is suitable for use in Western Blot, Immunohistochemistry and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Purification: |
Affinity purification |
| Concentration: |
0.8 mg/mL |
| Dilution Range: |
WB 1:500-2000, IHC 1:25-100 |
| Storage Instruction: |
Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Tissue Specificity | Ubiquitous. Strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain. In peripheral blood mononucleocytes, isoform 4 is mainly expressed and isoform 1 and isoform 7 are almost not expressed. Expression of isoform 1 and isoform 7 increases in leukemic cells. |
| Post Translational Modifications | Phosphorylation at Tyr-552 by SRC-family kinases recruits phosphoinositide-3-kinase (PI3K) PIK3CD:p85 heterodimer which results in integrin activation and leukocyte adhesion to activated endothelium during inflammation. |
| Function | Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3-mediated deubiquitination of IKBKG.proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway.blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity.this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation.this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. |
| Protein Name | Tnfaip3-Interacting Protein 1A20-Binding Inhibitor Of Nf-Kappa-B Activation 1Abin-1Hiv-1 Nef-Interacting ProteinNef-Associated Factor 1Naf1Nip40-1Virion-Associated Nuclear Shuttling ProteinVanHvan |
| Database Links | Reactome: R-HSA-5689896 |
| Cellular Localisation | CytoplasmNucleusShuttles Between The Nucleus And Cytoplasm In A Crm1-Dependent Manner |
| Alternative Antibody Names | Anti-Tnfaip3-Interacting Protein 1 antibodyAnti-A20-Binding Inhibitor Of Nf-Kappa-B Activation 1 antibodyAnti-Abin-1 antibodyAnti-Hiv-1 Nef-Interacting Protein antibodyAnti-Nef-Associated Factor 1 antibodyAnti-Naf1 antibodyAnti-Nip40-1 antibodyAnti-Virion-Associated Nuclear Shuttling Protein antibodyAnti-Van antibodyAnti-Hvan antibodyAnti-TNIP1 antibodyAnti-KIAA0113 antibodyAnti-NAF1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
