| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-TMPRSS4 (245-57) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:1000.WB: Approx. 48kDa band observed in lysates of cell lines HEK293 and A549 (calculated MW of 48.2kDa according to NP_063947.1). Recommended concentration: 0.3-1µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | TMPRSS4 |
| Gene ID: | 56649 |
| Uniprot ID: | TMPS4_HUMAN |
| Immunogen Region: | 245-57 |
| Accession Number: | NP_063947.1; NP_001077416.1 |
| Specificity: | This antibody is expected to recognise both reported isoforms (NP_063947.1 and NP_001077416.1). |
| Immunogen Sequence: | HCFRKHTDVFNWK |
| Post Translational Modifications | Proteolytically processed.probably by an autocatalytic mechanism. |
| Function | Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity. Seems to be capable of activating ENaC. (Microbial infection) In gut epithelial cells, facilitates human coronavirus SARS-CoV-2 infection through, at least, the cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry. |
| Protein Name | Transmembrane Protease Serine 4Channel-Activating Protease 2Caph2Membrane-Type Serine Protease 2Mt-Sp2 Cleaved Into - Transmembrane Protease Serine 4 Catalytic Chain |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinTransmembrane Protease Serine 4 Catalytic Chain: SecretedActivated By Cleavage And Secreted |
| Alternative Antibody Names | Anti-Transmembrane Protease Serine 4 antibodyAnti-Channel-Activating Protease 2 antibodyAnti-Caph2 antibodyAnti-Membrane-Type Serine Protease 2 antibodyAnti-Mt-Sp2 Cleaved Into - Transmembrane Protease Serine 4 Catalytic Chain antibodyAnti-TMPRSS4 antibodyAnti-TMPRSS3 antibodyAnti-UNQ776 antibodyAnti-PRO1570 antibody |
Information sourced from Uniprot.org