| Short Description : | Rabbit polyclonal TMEM2 (1150-1250) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CEMIP2 |
| Gene ID: | 23670 |
| Uniprot ID: | CEIP2_HUMAN |
| Immunogen Region: | 1150-1250 |
| Immunogen Sequence: | ERVKIQAATDSKDISNCMAK AYPQYYRKPSVVKRMPAMLT GLCQGCGTRQVVFTSDPHKS YLPVQFQSPDKAETQRGDPS VISVNGTDFTFRSAGVLLLV V |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1150-1250 of human TMEM2 (NP_037522.1). |
| Tissue Specificity | Widely expressed. |
| Function | Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 10-5 kDa fragments. Very specific to hyaluronan.not able to cleave chondroitin sulfate or dermatan sulfate. Has an essential function in systemic hyaluronan catabolism and turnover and regulates cell adhesion and migration via hyaluronan degradation at focal adhesion sites. Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling. |
| Protein Name | Cell Surface Hyaluronidase Cemip2Cell Migration-Inducing Hyaluronidase 2Transmembrane Protein 2 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Cell Surface Hyaluronidase Cemip2 antibodyAnti-Cell Migration-Inducing Hyaluronidase 2 antibodyAnti-Transmembrane Protein 2 antibodyAnti-CEMIP2 antibodyAnti-KIAA1412 antibodyAnti-TMEM2 antibody |
Information sourced from Uniprot.org
