| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TMEM119 (160-270) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TMEM119 |
| Gene ID: |
338773 |
| Uniprot ID: |
TM119_HUMAN |
| Immunogen Region: |
160-270 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 160-270 of human TMEM119 (NP_859075.2). |
| Immunogen Sequence: |
SRPEEALDSSRQLQADILAA TQNLKSPTRAALGGGDGARM VEGRGAEEEEKGSQEGDQEV QGHGVPVETPEAQEEPCSGV LEGAVVAGEGQGELEGSLLL AQEAQGPVGPP |
| Tissue Specificity | Expressed in brain microglia (at protein level). Elevated expression levels seen in the brain of patients with Alzheimer disease. Expressed by osteoblast-like cells in bone tissues and follicular dendritic cells in lymphoid tissues. |
| Function | Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts. May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation. |
| Protein Name | Transmembrane Protein 119Osteoblast Induction FactorObif |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCytoplasmEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Transmembrane Protein 119 antibodyAnti-Osteoblast Induction Factor antibodyAnti-Obif antibodyAnti-TMEM119 antibodyAnti-PSEC0199 antibodyAnti-UNQ731 antibodyAnti-PRO1415 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
