Anti-TMEM100 antibody (50-100 aa) (STJ193978)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human TM100 at the amino acid range 50-100
General Information
| Short Description | Rabbit polyclonal anti-Transmembrane protein 100 (50-100 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TMEM100 |
| Gene ID | 55273 |
| Uniprot ID | TM100_HUMAN |
| Immunogen | Synthesized peptide derived from the human TM100 at the amino acid range 50-100 |
| Immunogen Region | 50-100 aa |
| Specificity | This antibody detects endogenous levels of TM100 at Human/Mouse/Rat |
Additional Info
| Function | Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex. |
| Protein Name | Transmembrane Protein 100 |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMembranePerikaryonCytoplasmPerinuclear RegionEndoplasmic ReticulumColocalized With Hspa5 In The Endoplasmic Reticulum (Er)Enriched In Er MicrosomeColocalized With Bmp4 In Neural Cell Bodies And Neural Fibers Of The Enteric Nervous System |
| Alternative Antibody Names | Anti-Transmembrane Protein 100 antibodyAnti-TMEM100 antibody |
Information sourced from Uniprot.org