• Western blot analysis of lysates from K562 cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-TMEM100 antibody (50-100 aa) (STJ193978)

SKU:
STJ193978

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Transmembrane protein 100 (50-100 aa) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TMEM100
Gene ID: 55273
Uniprot ID: TM100_HUMAN
Immunogen Region: 50-100 aa
Specificity: This antibody detects endogenous levels of TM100 at Human/Mouse/Rat
Immunogen: Synthesized peptide derived from the human TM100 at the amino acid range 50-100
Function Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex.
Protein Name Transmembrane Protein 100
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Membrane
Perikaryon
Cytoplasm
Perinuclear Region
Endoplasmic Reticulum
Colocalized With Hspa5 In The Endoplasmic Reticulum (Er)
Enriched In Er Microsome
Colocalized With Bmp4 In Neural Cell Bodies And Neural Fibers Of The Enteric Nervous System
Alternative Antibody Names Anti-Transmembrane Protein 100 antibody
Anti-TMEM100 antibody

Information sourced from Uniprot.org

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