Anti-TLR6 antibody (195-225) {Biotin} (STJ503303)

SKU:
STJ503303-100

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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Cat/Human/Mouse/Pig/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TLR6 (195-225) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.78-0.80 µg/µl
Dilution Range: WB: 1:500
DB: 1:20, 000
ELISA: 1:20, 000
IP: 1:200
IHC: 1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: TLR6
Gene ID: 10333
Uniprot ID: TLR6_HUMAN
Immunogen Region: 195-225
Immunogen: Synthetic peptide taken within amino acid region 195-225 on human TLR6 protein.
Tissue Specificity Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.
Function Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.
Protein Name Toll-Like Receptor 6
Cd Antigen Cd286
Database Links Reactome: R-HSA-1236974
Reactome: R-HSA-166058
Reactome: R-HSA-168188
Reactome: R-HSA-5602498
Reactome: R-HSA-5603041
Reactome: R-HSA-5686938
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cytoplasmic Vesicle
Phagosome Membrane
Membrane Raft
Golgi Apparatus
Upon Complex Formation With Cd36 And Tlr4
Internalized Through Dynamin-Dependent Endocytosis
Does Not Reside In Lipid Rafts Before Stimulation But Accumulates Increasingly In The Raft Upon The Presence Of The Microbial Ligand
In Response To Diacylated Lipoproteins
Tlr2:Tlr6 Heterodimers Are Recruited In Lipid Rafts
This Recruitment Determine The Intracellular Targeting To The Golgi Apparatus
Alternative Antibody Names Anti-Toll-Like Receptor 6 antibody
Anti-Cd Antigen Cd286 antibody
Anti-TLR6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance