| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TLK2 |
| Gene ID: |
11011 |
| Uniprot ID: |
TLK2_HUMAN |
| Immunogen Region: |
1-220 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human TLK2 (NP_006843.2). |
| Immunogen Sequence: |
MMEELHSLDPRRQELLEARF TGVGVSKGPLNSESSNQSLC SVGSLSDKEVETPEKKQNDQ RNRKRKAEPYETSQGKGTPR GHKISDYFEFAGGSAPGTSP GRSVPPVARSSPQHSLSNPL PRRVEQPLYGLDGSAAKEAT EEQSALPTLMSVMLAKPRLD TEQLAQRGAGLCFTFVSAQQ NSPSSTGSGNTEHSCSSQKQ ISIQHRQTQSDLTIEKISAL |
| Tissue Specificity | Detected in placenta, fetal liver, kidney, pancreas, heart and skeletal muscle. Highly expressed in testis. Detected in spleen, thymus, colon, ovary, small intestine, prostate and peripheral blood leukocytes. Almost undetectable in liver and lung. |
| Post Translational Modifications | Phosphorylated at Ser-750, probably by CHEK1. Autophosphorylated.phosphorylation promotes the assembly of higher order oligomers and enzymatic activity. |
| Function | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A and ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy. |
| Protein Name | Serine/Threonine-Protein Kinase Tousled-Like 2HshpkPku-AlphaTousled-Like Kinase 2 |
| Cellular Localisation | NucleusNucleoplasmCytoplasmPerinuclear RegionCytoskeletonColocalizes With The Cytoplasmic Intermediate Filament System During The G1 Phase Of The Cell CyclePresent In The Perinuclear Region At S Phase And In The Nucleus At Late G2 |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Tousled-Like 2 antibodyAnti-Hshpk antibodyAnti-Pku-Alpha antibodyAnti-Tousled-Like Kinase 2 antibodyAnti-TLK2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
