Anti-TLE3 antibody (257-307 aa) (STJ193803)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human TLE3 at the amino acid range 257-307
General Information
| Short Description | Rabbit polyclonal anti-Transducin-like enhancer protein 3 (257-307 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TLE3 |
| Gene ID | 7090 |
| Uniprot ID | TLE3_HUMAN |
| Immunogen | Synthesized peptide derived from the human TLE3 at the amino acid range 257-307 |
| Immunogen Region | 257-307 aa |
| Specificity | This antibody detects endogenous levels of TLE3 at Human/Mouse/Rat |
Additional Info
| Post Translational Modifications | Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4. Ubiquitinated at Lys-720 by UBR5 in response to Wnt signaling, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome. |
| Function | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. |
| Protein Name | Transducin-Like Enhancer Protein 3Enhancer Of Split Groucho-Like Protein 3Esg3 |
| Database Links | Reactome: R-HSA-201722Reactome: R-HSA-2122947 Q04726-3Reactome: R-HSA-3769402Reactome: R-HSA-4641265Reactome: R-HSA-9018519 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transducin-Like Enhancer Protein 3 antibodyAnti-Enhancer Of Split Groucho-Like Protein 3 antibodyAnti-Esg3 antibodyAnti-TLE3 antibodyAnti-KIAA1547 antibody |
Information sourced from Uniprot.org