| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Transducin-like enhancer protein 3 (257-307 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TLE3 |
| Gene ID: |
7090 |
| Uniprot ID: |
TLE3_HUMAN |
| Immunogen Region: |
257-307 aa |
| Specificity: |
This antibody detects endogenous levels of TLE3 at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human TLE3 at the amino acid range 257-307 |
| Post Translational Modifications | Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4. |
| Function | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. |
| Protein Name | Transducin-Like Enhancer Protein 3Enhancer Of Split Groucho-Like Protein 3Esg3 |
| Database Links | Reactome: R-HSA-201722Reactome: R-HSA-2122947 Q04726-3Reactome: R-HSA-3769402Reactome: R-HSA-4641265Reactome: R-HSA-9018519 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transducin-Like Enhancer Protein 3 antibodyAnti-Enhancer Of Split Groucho-Like Protein 3 antibodyAnti-Esg3 antibodyAnti-TLE3 antibodyAnti-KIAA1547 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
