| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-TINF2 (202-451) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TINF2 |
| Gene ID: | 26277 |
| Uniprot ID: | TINF2_HUMAN |
| Immunogen Region: | 202-451 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 202-451 of human TIN2/TIN2/TINF2 (NP_001092744.1). |
| Immunogen Sequence: | ECSVTDSVNLAEPMEQNPPQ QQRLALHNPLPKAKPGTHLP QGPSSRTHPEPLAGRHFNLA PLGRRRVQSQWASTRGGHKE RPTVMLFPFRNLGSPTQVIS KPESKEEHAIYTADLAMGTR AASTGKSKSPCQTLGGRALK ENPVDLPATEQKENCLDCYM DPLRLSLLPPRARKPVCPPS LCSSVITIGDLVLDSDEEEN GQGEGKESLENYQKTKFDTL IPTLCEYLPPSGHGAIPVS |
| Tissue Specificity | Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Function | Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends.without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. |
| Protein Name | Terf1-Interacting Nuclear Factor 2Trf1-Interacting Nuclear Protein 2 |
| Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-110330Reactome: R-HSA-110331Reactome: R-HSA-1221632Reactome: R-HSA-171306Reactome: R-HSA-171319Reactome: R-HSA-174411Reactome: R-HSA-174414Reactome: R-HSA-174417Reactome: R-HSA-174430Reactome: R-HSA-174437Reactome: R-HSA-2559586Reactome: R-HSA-9670095 |
| Cellular Localisation | NucleusChromosomeTelomereAssociated With TelomeresIsoform 1: Nucleus Matrix |
| Alternative Antibody Names | Anti-Terf1-Interacting Nuclear Factor 2 antibodyAnti-Trf1-Interacting Nuclear Protein 2 antibodyAnti-TINF2 antibodyAnti-TIN2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and STIM1 knockout (KO) HeLa cells, using [KO Validated] STIM1 Rabbit polyclonal antibody (STJ11100770) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89707/358189/STJ11100770_1__47615.1713122504.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and STIM1 knockout (KO) HeLa cells, using [KO Validated] STIM1 Rabbit polyclonal antibody (STJ11100770) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
