| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TINF2 |
| Gene ID: | 26277 |
| Uniprot ID: | TINF2_HUMAN |
| Immunogen Region: | 202-451 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 202-451 of human TIN2/TIN2/TINF2 (NP_001092744.1). |
| Immunogen Sequence: | ECSVTDSVNLAEPMEQNPPQ QQRLALHNPLPKAKPGTHLP QGPSSRTHPEPLAGRHFNLA PLGRRRVQSQWASTRGGHKE RPTVMLFPFRNLGSPTQVIS KPESKEEHAIYTADLAMGTR AASTGKSKSPCQTLGGRALK ENPVDLPATEQKENCLDCYM DPLRLSLLPPRARKPVCPPS LCSSVITIGDLVLDSDEEEN GQGEGKESLENYQKTKFDTL IPTLCEYLPPSGHGAIPVS |
| Tissue Specificity | Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Function | Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends.without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. |
| Protein Name | Terf1-Interacting Nuclear Factor 2 Trf1-Interacting Nuclear Protein 2 |
| Database Links | Reactome: R-HSA-110328 Reactome: R-HSA-110329 Reactome: R-HSA-110330 Reactome: R-HSA-110331 Reactome: R-HSA-1221632 Reactome: R-HSA-171306 Reactome: R-HSA-171319 Reactome: R-HSA-174411 Reactome: R-HSA-174414 Reactome: R-HSA-174417 Reactome: R-HSA-174430 Reactome: R-HSA-174437 Reactome: R-HSA-2559586 Reactome: R-HSA-9670095 |
| Cellular Localisation | Nucleus Chromosome Telomere Associated With Telomeres Isoform 1: Nucleus Matrix |
| Alternative Antibody Names | Anti-Terf1-Interacting Nuclear Factor 2 antibody Anti-Trf1-Interacting Nuclear Protein 2 antibody Anti-TINF2 antibody Anti-TIN2 antibody |
Information sourced from Uniprot.org