Anti-TIMP1 antibody (61-110 aa) (STJ96023)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human TIMP1 at the amino acid range 61-110
General Information
| Short Description | Rabbit polyclonal anti-Metalloproteinase inhibitor 1 (61-110 aa) for use in IF, WB, IHC and ELISA in Human, Mouse, Rat and Rabbit samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/WB/IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat/Rabbit |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IF 1:50-200WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TIMP1 |
| Gene ID | 7076 |
| Uniprot ID | TIMP1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human TIMP1 at the amino acid range 61-110 |
| Immunogen Region | 61-110 aa |
| Specificity | TIMP-1 Polyclonal Antibody detects endogenous levels of TIMP-1 protein. |
Additional Info
| Post Translational Modifications | The activity of TIMP1 is dependent on the presence of disulfide bonds. N-glycosylated. |
| Function | Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro.but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. |
| Protein Name | Metalloproteinase Inhibitor 1Erythroid-Potentiating ActivityEpaFibroblast Collagenase InhibitorCollagenase InhibitorTissue Inhibitor Of Metalloproteinases 1Timp-1 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-1592389Reactome: R-HSA-381426Reactome: R-HSA-6783783Reactome: R-HSA-6785807Reactome: R-HSA-8957275Reactome: R-HSA-9839383 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Metalloproteinase Inhibitor 1 antibodyAnti-Erythroid-Potentiating Activity antibodyAnti-Epa antibodyAnti-Fibroblast Collagenase Inhibitor antibodyAnti-Collagenase Inhibitor antibodyAnti-Tissue Inhibitor Of Metalloproteinases 1 antibodyAnti-Timp-1 antibodyAnti-TIMP1 antibodyAnti-CLGI antibodyAnti-TIMP antibody |
Information sourced from Uniprot.org