| Short Description : | Rabbit polyclonal TIMM8B (16-98) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:100IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TIMM8B |
| Gene ID: | 26521 |
| Uniprot ID: | TIM8B_HUMAN |
| Immunogen Region: | 16-98 |
| Immunogen Sequence: | MAELGEADEAELQRLVAAEQ QKAQFTAQVHHFMELCWDKC VEKPGNRLDSRTENCLSSCV DRFIDTTLAITSRFAQIVQK GGQ |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 16-98 of human TIMM8B (NP_036591.1). |
| Tissue Specificity | Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle. |
| Function | Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. |
| Protein Name | Mitochondrial Import Inner Membrane Translocase Subunit Tim8 BDdp-Like ProteinDeafness Dystonia Protein 2 |
| Database Links | Reactome: R-HSA-1268020 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinIntermembrane Side |
| Alternative Antibody Names | Anti-Mitochondrial Import Inner Membrane Translocase Subunit Tim8 B antibodyAnti-Ddp-Like Protein antibodyAnti-Deafness Dystonia Protein 2 antibodyAnti-TIMM8B antibodyAnti-DDP2 antibodyAnti-DDPL antibodyAnti-TIM8B antibody |
Information sourced from Uniprot.org
![Immunofluorescence analysis of NIH/3T3 cells using [KD Validated] COX IV Rabbit polyclonal antibody (STJ11104961) at dilution of 1:50 (40x lens). Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/177605/369461/STJ11104961_1__90609.1713134964.jpg?c=1 "Immunofluorescence analysis of NIH/3T3 cells using [KD Validated] COX IV Rabbit polyclonal antibody (STJ11104961) at dilution of 1:50 (40x lens). Blue: DAPI for nuclear staining.")
