| Host: | Rabbit |
| Applications: | WB/IP/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IP:0.5 Mu g-4 Mu g antibody for 400 Mu g-600 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Timm22 |
| Gene ID: | 56322 |
| Uniprot ID: | TIM22_MOUSE |
| Immunogen Region: | 19-121 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-121 of mouse Timm22 (NP_062792.2). |
| Immunogen Sequence: | AEAPLQYSLLLQYLVGDKRQ PRLLEPGSLGGIPSPAKSEE QKMIERAMESCAFKAVLACV GGFVLGGAFGIFTAGIDTNV GFDPKDPYRTPTAKEVLKDM GQR |
| Post Translational Modifications | Disulfide bonds promote efficient assembly of the TIM22 complex. |
| Function | Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps. |
| Protein Name | Mitochondrial Import Inner Membrane Translocase Subunit Tim22 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mitochondrial Import Inner Membrane Translocase Subunit Tim22 antibodyAnti-Timm22 antibodyAnti-Tim22 antibody |
Information sourced from Uniprot.org