| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TIGIT (167-244) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TIGIT |
| Gene ID: |
201633 |
| Uniprot ID: |
TIGIT_HUMAN |
| Immunogen Region: |
167-244 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 167-244 of human TIGIT (NP_776160.2). |
| Immunogen Sequence: |
KKALRIHSVEGDLRRKSAGQ EEWSPSAPSPPGSCVQAEAA PAGLCGEQRGEDCAELHDYF NVLSYRSLGNCSFFTETG |
| Tissue Specificity | Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). |
| Function | Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. |
| Protein Name | T-Cell Immunoreceptor With Ig And Itim DomainsV-Set And Immunoglobulin Domain-Containing Protein 9V-Set And Transmembrane Domain-Containing Protein 3 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-T-Cell Immunoreceptor With Ig And Itim Domains antibodyAnti-V-Set And Immunoglobulin Domain-Containing Protein 9 antibodyAnti-V-Set And Transmembrane Domain-Containing Protein 3 antibodyAnti-TIGIT antibodyAnti-VSIG9 antibodyAnti-VSTM3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
