| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MYO18A |
| Uniprot ID: | TIAF1_HUMAN |
| Immunogen Region: | 1-115 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-115 of human TIAF1 (NP_004731.2). |
| Immunogen Sequence: | MSSPSSPFREQSFLCAAGDA GEESRVQVLKNEVRRGSPVL LGWVEQAYADKCVCGPSAPP APTPPSLSQRVMCNDLFKVN PFQLQQFRADPSTASLLLCP GGLDHKLNLRGKAWG |
| Tissue Specificity | Not detectable in normal kidney and liver. Up-regulated in chronic and acute allograft rejection: expressed in the inflammatory infiltrate and in tubular epithelial cells. |
| Function | Isoform TIAF1: Inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation. |
| Protein Name | Putative Tgfb1-Induced Anti-Apoptotic Factor 112 Kda Tgf-Beta-1-Induced Antiapoptotic Factor |
| Cellular Localisation | Isoform Tiaf1: Nucleus |
| Alternative Antibody Names | Anti-Putative Tgfb1-Induced Anti-Apoptotic Factor 1 antibodyAnti-12 Kda Tgf-Beta-1-Induced Antiapoptotic Factor antibodyAnti-MYO18A antibodyAnti-TIAF1 antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and CDK2AP1 knockout (KO) 293T cells, using [KO Validated] CDK2AP1 Rabbit polyclonal antibody (STJ11100861) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/89795/358264/STJ11100861_1__24480.1713122604.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and CDK2AP1 knockout (KO) 293T cells, using [KO Validated] CDK2AP1 Rabbit polyclonal antibody (STJ11100861) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.")
