| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GOSR1 (1-115) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GOSR1 |
| Gene ID: |
9527 |
| Uniprot ID: |
GOSR1_HUMAN |
| Immunogen Region: |
1-115 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-115 of human GOSR1 (NP_004862.1). |
| Immunogen Sequence: |
MAAGTSSYWEDLRKQARQLE NELDLKLVSFSKLCTSYSHS STRDGRRDRYSSDTTPLLNG SSQDRMFETMAIEIEQLLAR LTGVNDKMAEYTNSAGVPSL NAALMHTLQRHRDIL |
| Function | Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. |
| Protein Name | Golgi Snap Receptor Complex Member 128 Kda Golgi Snare Protein28 Kda Cis-Golgi Snare P28Gos-28 |
| Database Links | Reactome: R-HSA-6807878Reactome: R-HSA-6811438 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Iv Membrane ProteinLocalizes Throughout The Golgi ApparatusWith Lowest Levels In The Trans-Golgi NetworkEnriched On Vesicular Components At The Terminal Rims Of The GolgiFound In Golgi Microtubules At Low Temperature (15 Degrees Celsius) |
| Alternative Antibody Names | Anti-Golgi Snap Receptor Complex Member 1 antibodyAnti-28 Kda Golgi Snare Protein antibodyAnti-28 Kda Cis-Golgi Snare P28 antibodyAnti-Gos-28 antibodyAnti-GOSR1 antibodyAnti-GS28 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
