| Short Description : | Rabbit polyclonal THRA (138-489) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | THRA |
| Gene ID: | 7067 |
| Uniprot ID: | THA_HUMAN |
| Immunogen Region: | 138-489 |
| Immunogen Sequence: | IEQNRERRRKEEMIRSLQQR PEPTPEEWDLIHIATEAHRS TNA |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 138-180 of human THRA (NP_003241.2). |
| Function | Isoform Alpha-1: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Isoform Alpha-2: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action. |
| Protein Name | Thyroid Hormone Receptor AlphaNuclear Receptor Subfamily 1 Group A Member 1V-Erba-Related Protein 7Ear-7C-Erba-1C-Erba-Alpha |
| Database Links | Reactome: R-HSA-383280Reactome: R-HSA-4090294 P10827-2 |
| Cellular Localisation | NucleusIsoform Alpha-2: CytoplasmWhen Overexpressed Found In The Cytoplasm Where It Colocalizes With Tacc1 |
| Alternative Antibody Names | Anti-Thyroid Hormone Receptor Alpha antibodyAnti-Nuclear Receptor Subfamily 1 Group A Member 1 antibodyAnti-V-Erba-Related Protein 7 antibodyAnti-Ear-7 antibodyAnti-C-Erba-1 antibodyAnti-C-Erba-Alpha antibodyAnti-THRA antibodyAnti-EAR7 antibodyAnti-ERBA1 antibodyAnti-NR1A1 antibodyAnti-THRA1 antibodyAnti-THRA2 antibody |
Information sourced from Uniprot.org
