Anti-TGFB2/TGF-beta-2 antibody [SAA0444] (STJA0027621)

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STJA0027621
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Covered by St John's Laboratory Guarantee

Host: Mouse
Applications: ELISA/FC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-Transforming Growth Factor Beta-2 Proprotein is suitable for use in ELISA and Flow Cytometry research applications.
Clonality : Monoclonal
Clone ID : SAA0444
Conjugation: Unconjugated
Isotype: IgG2ak
Formulation: 0.01M PBS, pH 7.4, 0.09% Sodium azide.
Purification: Protein A/G purified from cell culture supernatant.
Concentration: 1 mg/ml
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: TGFB2
Gene ID: 7042
Uniprot ID: TGFB2_HUMAN
Function Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Latency-associated peptide: Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus. Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal.
Protein Name Transforming Growth Factor Beta-2 Proprotein
Cetermin
Glioblastoma-Derived T-Cell Suppressor Factor
G-Tsf Cleaved Into - Latency-Associated Peptide
Lap - Transforming Growth Factor Beta-2
Tgf-Beta-2
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-2129379
Reactome: R-HSA-2173789
Reactome: R-HSA-3000178
Reactome: R-HSA-9839389
Cellular Localisation Latency-Associated Peptide: Secreted
Extracellular Space
Extracellular Matrix
Transforming Growth Factor Beta-2: Secreted
Alternative Antibody Names Anti-Transforming Growth Factor Beta-2 Proprotein antibody
Anti-Cetermin antibody
Anti-Glioblastoma-Derived T-Cell Suppressor Factor antibody
Anti-G-Tsf Cleaved Into - Latency-Associated Peptide antibody
Anti-Lap - Transforming Growth Factor Beta-2 antibody
Anti-Tgf-Beta-2 antibody
Anti-TGFB2 antibody

Information sourced from Uniprot.org

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