Anti-TFB2M antibody (C-Term) (STJ70255)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-TFB2M (C-Term) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/IHC |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Preliminary experiments gave an approx 40kDa band in Human Brain lysate at 0.3 ug/ml. Please note that currently we cannot find an explanation in the literature for the band we observ |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | TFB2M |
| Gene ID | 64216 |
| Uniprot ID | TFB2M_HUMAN |
| Accession Number | NP_071761.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | CAYKWLYDETLEDR |
Additional Info
| Function | S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (Probable). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Stimulates transcription independently of the methyltransferase activity. |
| Protein Name | Dimethyladenosine Transferase 2 - MitochondrialHepatitis C Virus Ns5a-Transactivated Protein 5Hcv Ns5a-Transactivated Protein 5Mitochondrial 12s Rrna Dimethylase 2Mitochondrial Transcription Factor B2H-MttfbH-Mttfb2Htfb2mMttfb2S-Adenosylmethionine-6-N' - N'-Adenosyl(Rrna Dimethyltransferase 2 |
| Database Links | Reactome: R-HSA-163282Reactome: R-HSA-2151201 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Dimethyladenosine Transferase 2 - Mitochondrial antibodyAnti-Hepatitis C Virus Ns5a-Transactivated Protein 5 antibodyAnti-Hcv Ns5a-Transactivated Protein 5 antibodyAnti-Mitochondrial 12s Rrna Dimethylase 2 antibodyAnti-Mitochondrial Transcription Factor B2 antibodyAnti-H-Mttfb antibodyAnti-H-Mttfb2 antibodyAnti-Htfb2m antibodyAnti-Mttfb2 antibodyAnti-S-Adenosylmethionine-6-N' - N'-Adenosyl(Rrna Dimethyltransferase 2 antibodyAnti-TFB2M antibodyAnti-NS5ATP5 antibody |
Information sourced from Uniprot.org