| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TDRD3 |
| Gene ID: | 81550 |
| Uniprot ID: | TDRD3_HUMAN |
| Immunogen Region: | 1-220 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human TDRD3 (NP_110421.1). |
| Immunogen Sequence: | MLRLQMTDGHISCTAVEFSY MSKISLNTPPGTKVKLSGIV DIKNGFLLLNDSNTTVLGGE VEHLIEKWELQRSLSKHNRS NIGTEGGPPPFVPFGQKCVS HVQVDSRELDRRKTLQVTMP VKPTNDNDEFEKQRTAAIAE VAKSKETKTFGGGGGGARSN LNMNAAGNRNREVLQKEKST KSEGKHEGVYRELVDEKALK HITEMGFSKEASRQALMDNG |
| Tissue Specificity | Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Post Translational Modifications | Probably cleaved by enteroviral 2A proteinase. |
| Function | Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1. |
| Protein Name | Tudor Domain-Containing Protein 3 |
| Cellular Localisation | CytoplasmNucleusPredominantly CytoplasmicAssociated With Actively Translating PolyribosomesComponent Of Stress Granules |
| Alternative Antibody Names | Anti-Tudor Domain-Containing Protein 3 antibodyAnti-TDRD3 antibody |
Information sourced from Uniprot.org
