| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TCHH (100-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TCHH |
| Gene ID: |
7062 |
| Uniprot ID: |
TRHY_HUMAN |
| Immunogen Region: |
100-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human TCHH (NP_009044.2). |
| Immunogen Sequence: |
RARCDGKESLLQDRRQEEDQ RRFEPRDRQLEEEPGQRRRQ KRQEQERELAEGEEQSEKQE RLEQRDRQRRDEELWRQRQE WQEREERRAEEEQLQSCKGH ETEEFPDEEQLRRRELLELR RKGREEKQQQRRERQDRVFQ EEEEKEWRKRETVLRKEEEK LQEEEPQRQRELQEEEEQLR KLERQELRRERQEEEQQQQR L |
| Tissue Specificity | Found in the hard keratinizing tissues such as the inner root sheath (IRS) of hair follicles and medulla, and in the filiform papillae of dorsal tongue epithelium. |
| Post Translational Modifications | Substrate of transglutaminase. Some 200 arginines are probably converted to citrullines by peptidylarginine deimidase. |
| Function | Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation. |
| Protein Name | Trichohyalin |
| Database Links | Reactome: R-HSA-6809371 |
| Alternative Antibody Names | Anti-Trichohyalin antibodyAnti-TCHH antibodyAnti-THH antibodyAnti-THL antibodyAnti-TRHY antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
