| Short Description : | Rabbit polyclonal TBXAS1 (355-534) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TBXAS1 |
| Gene ID: | 6916 |
| Uniprot ID: | THAS_HUMAN |
| Immunogen Region: | 355-534 |
| Immunogen Sequence: | TYLLATNPDCQEKLLREVDV FKEKHMAPEFCSLEEGLPYL DMVIAETLRMYPPAFRFTRE AAQDCEVLGQRIPAGAVLEM AVGALHHDPEHWPSPETFNP ERFTAEARQQHRPFTYLPFG AGPRSCLGVRLGLLEVKLTL LHVLHKFRFQACPETQVPLQ LESKSALGPKNGVYIKIVSR |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 355-534 of human Thromboxane synthase (NP_001052.2). |
| Tissue Specificity | Platelets, lung, kidney, spleen, macrophages and lung fibroblasts. |
| Function | Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE. |
| Protein Name | Thromboxane-A SynthaseTxa SynthaseTxsCytochrome P450 5a1Hydroperoxy Icosatetraenoate Dehydratase |
| Database Links | Reactome: R-HSA-211979Reactome: R-HSA-2162123Reactome: R-HSA-5579032 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Thromboxane-A Synthase antibodyAnti-Txa Synthase antibodyAnti-Txs antibodyAnti-Cytochrome P450 5a1 antibodyAnti-Hydroperoxy Icosatetraenoate Dehydratase antibodyAnti-TBXAS1 antibodyAnti-CYP5 antibodyAnti-CYP5A1 antibodyAnti-TXAS antibody |
Information sourced from Uniprot.org
