| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TBRG1 (22-150) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TBRG1 |
| Gene ID: |
84897 |
| Uniprot ID: |
TBRG1_HUMAN |
| Immunogen Region: |
22-150 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 22-150 of human TBRG1 (NP_116200.2). |
| Immunogen Sequence: |
MKKLPKKSQNEKYRLKYLRL RKAAKATVFENAAICDEIAR LEEKFLKAKEERRYLLKKLL QLQALTEGEVQAAAPSHSSS LPLTYGVASSVGTIQGAGPI SGPSTGAEEPFGKKTKKEKK EKGKENNKL |
| Tissue Specificity | Widely expressed at low levels in most tissues, with highest levels in pancreas, lung and liver. Expression is decreased in primary tumors including lung, liver, breast, pancreas and kidney carcinomas, chronic lymphocytic leukemia and diffuse large B-cell lymphoma. |
| Post Translational Modifications | Ubiquitinated.mediated by MDM2 and leading to its subsequent proteasomal degradation. |
| Function | Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability. |
| Protein Name | Transforming Growth Factor Beta Regulator 1Nuclear Interactor Of Arf And Mdm2 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transforming Growth Factor Beta Regulator 1 antibodyAnti-Nuclear Interactor Of Arf And Mdm2 antibodyAnti-TBRG1 antibodyAnti-NIAM antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
