| Tissue Specificity | Widely expressed with highest levels in brain. Broadly distributed throughout the neonate brain but restricted mainly to ependymary cells in the adult brain where it is concentrated in the cilia. |
| Post Translational Modifications | Phosphorylation by PAK1 is required for normal function. Ubiquitinated in the presence of GAN which targets it for degradation by the proteasome. |
| Function | Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth. |
| Protein Name | Tubulin-Folding Cofactor BCytoskeleton-Associated Protein 1Cytoskeleton-Associated Protein CkapiTubulin-Specific Chaperone B |
| Cellular Localisation | CytoplasmCytoskeletonColocalizes With MicrotubulesIn Differentiated NeuronsLocated In The CytoplasmIn Differentiating NeuronsAccumulates At The Growth Cone |
| Alternative Antibody Names | Anti-Tubulin-Folding Cofactor B antibodyAnti-Cytoskeleton-Associated Protein 1 antibodyAnti-Cytoskeleton-Associated Protein Ckapi antibodyAnti-Tubulin-Specific Chaperone B antibodyAnti-Tbcb antibodyAnti-Ckap1 antibody |
Information sourced from Uniprot.org
