• Western blot analysis of lysates from HT29 cells, using I-TRAF Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of HT-29 cells using TANK Polyclonal Antibody

Anti-TANK antibody (171-220 aa) (STJ95905)

SKU:
STJ95905

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TRAF family member-associated NF-kappa-B activator (171-220 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TANK
Gene ID: 10010
Uniprot ID: TANK_HUMAN
Immunogen Region: 171-220 aa
Specificity: TANK Polyclonal Antibody detects endogenous levels of TANK protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human TANK at the amino acid range 171-220
Post Translational Modifications Phosphorylated by IKBKE. (Microbial infection) Cleaved by encephalomyocarditis virus (EMCV) protease 3C. This cleavage allows the virus to disrupt the TANK-TBK1-IKKepsilon-IRF3 complex, thereby inhibiting the induction of the IFN-beta signal pathway. (Microbial infection) Cleaved by Seneca Valley virus protease 3C allowing the virus to suppress interferon type-I through both RIG-I and Toll-like receptor-dependent pathways.
Function Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage. Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage. Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage. May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.
Protein Name Traf Family Member-Associated Nf-Kappa-B Activator
Traf-Interacting Protein
I-Traf
Database Links Reactome: R-HSA-9013973
Reactome: R-HSA-933541
Reactome: R-HSA-936964
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Traf Family Member-Associated Nf-Kappa-B Activator antibody
Anti-Traf-Interacting Protein antibody
Anti-I-Traf antibody
Anti-TANK antibody
Anti-ITRAF antibody
Anti-TRAF2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance