Anti-TAFA5 antibody (370-450 aa) (STJ192493)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 370-450
General Information
| Short Description | Rabbit polyclonal anti-Chemokine-like protein TAFA-5 (370-450 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TAFA5 |
| Gene ID | 25817 |
| Uniprot ID | TAFA5_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 370-450 |
| Immunogen Region | 370-450 aa |
| Specificity | F19A5 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2. Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway. Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes. Stimulation of macrophage migration and inhibition of osteoclast formation is mediated via GPCR FPR2. Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling. Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries. |
| Protein Name | Chemokine-Like Protein Tafa-5 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Chemokine-Like Protein Tafa-5 antibodyAnti-TAFA5 antibodyAnti-FAM19A5 antibodyAnti-UNQ5208 antibodyAnti-PRO34524 antibody |
Information sourced from Uniprot.org