| Host: | Rabbit |
| Applications: | WB/IP/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TAF6L |
| Gene ID: | 10629 |
| Uniprot ID: | TAF6L_HUMAN |
| Immunogen Region: | 1-200 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human TAF6L (NP_006464.1). |
| Immunogen Sequence: | MSEREERRFVEIPRESVRLM AESTGLELSDEVAALLAEDV CYRLREATQNSSQFMKHTKR RKLTVEDFNRALRWSSVEAV CGYGSQEALPMRPAREGELY FPEDREVNLVELALATNIPK GCAETAVRVHVSYLDGKGNL APQGSVPSAVSSLTDDLLKY YHQVTRAVLGDDPQLMKVAL QDLQTNSKIGALLPYFVYVV |
| Function | Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. Functions with MYC to activate target gene expression through RNA polymerase II pause release. |
| Protein Name | Taf6-Like Rna Polymerase Ii P300/Cbp-Associated Factor-Associated Factor 65 Kda Subunit 6lTaf6lPcaf-Associated Factor 65-AlphaPaf65-Alpha |
| Database Links | Reactome: R-HSA-3214847 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Taf6-Like Rna Polymerase Ii P300/Cbp-Associated Factor-Associated Factor 65 Kda Subunit 6l antibodyAnti-Taf6l antibodyAnti-Pcaf-Associated Factor 65-Alpha antibodyAnti-Paf65-Alpha antibodyAnti-TAF6L antibodyAnti-PAF65A antibody |
Information sourced from Uniprot.org