| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TAF6 |
| Gene ID: | 6878 |
| Uniprot ID: | TAF6_HUMAN |
| Immunogen Region: | 350-450 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human TAF6 (XP_006716164.1). |
| Immunogen Sequence: | TKSWVDEKTPWTTRYGSIAG LAELGHDVIKTLILPRLQQE GERIRSVLDGPVLSNIDRIG ADHVQSLLLKHCAPVLAKLR PPPDNQDAYRAEFGSLGPLL C |
| Post Translational Modifications | Isoform 4: In cells undergoing apoptosis, cleaved in a caspase-dependent manner to produce a 40 kDa product. |
| Function | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C. TAF6 homodimer connects TFIID modules, forming a rigid core. Isoform 4: Transcriptional regulator which acts primarily as a positive regulator of transcription. Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis. Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1. In contrast, down-regulates transcription of MDM2. Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1. Can also activate transcription and apoptosis independently of TP53. Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA. |
| Protein Name | Transcription Initiation Factor Tfiid Subunit 6 Rna Polymerase Ii Tbp-Associated Factor Subunit E Transcription Initiation Factor Tfiid 70 Kda Subunit Taf(Ii70 Tafii-70 Tafii70 Transcription Initiation Factor Tfiid 80 Kda Subunit Taf(Ii80 Tafii-80 Tafii80 |
| Database Links | Reactome: R-HSA-167161 Reactome: R-HSA-167162 Reactome: R-HSA-167172 Reactome: R-HSA-674695 Reactome: R-HSA-6804756 Reactome: R-HSA-6807505 Reactome: R-HSA-73776 Reactome: R-HSA-73779 Reactome: R-HSA-75953 Reactome: R-HSA-76042 |
| Cellular Localisation | Nucleus Isoform 4: Nucleus |
| Alternative Antibody Names | Anti-Transcription Initiation Factor Tfiid Subunit 6 antibody Anti-Rna Polymerase Ii Tbp-Associated Factor Subunit E antibody Anti-Transcription Initiation Factor Tfiid 70 Kda Subunit antibody Anti-Taf(Ii70 antibody Anti-Tafii-70 antibody Anti-Tafii70 antibody Anti-Transcription Initiation Factor Tfiid 80 Kda Subunit antibody Anti-Taf(Ii80 antibody Anti-Tafii-80 antibody Anti-Tafii80 antibody Anti-TAF6 antibody Anti-TAF2E antibody Anti-TAFII70 antibody |
Information sourced from Uniprot.org