| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TAC1 |
| Gene ID: | 6863 |
| Uniprot ID: | TKN1_HUMAN |
| Immunogen Region: | 1-129 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-129 of human TAC1 (NP_003173.1). |
| Immunogen Sequence: | MKILVALAVFFLVSTQLFAE EIGANDDLNYWSDWYDSDQI KEELPEPFEHLLQRIARRPK PQQFFGLMGKRDADSSIEKQ VALLKALYGHGQISHKRHKT DSFVGLMGKRALNSVAYERS AMQNYERRR |
| Post Translational Modifications | Substance P: The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro). Substance P is also cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME). |
| Function | Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. |
| Protein Name | Protachykinin-1 Ppt Cleaved Into - Substance P - Neurokinin A Nka Neuromedin L Substance K - Neuropeptide K Npk - Neuropeptide Gamma - C-Terminal-Flanking Peptide |
| Database Links | Reactome: R-HSA-380095 Reactome: R-HSA-416476 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Protachykinin-1 antibody Anti-Ppt Cleaved Into - Substance P - Neurokinin A antibody Anti-Nka antibody Anti-Neuromedin L antibody Anti-Substance K - Neuropeptide K antibody Anti-Npk - Neuropeptide Gamma - C-Terminal-Flanking Peptide antibody Anti-TAC1 antibody Anti-NKA antibody Anti-NKNA antibody Anti-TAC2 antibody |
Information sourced from Uniprot.org