| Host: | Mouse |
| Applications: | WB/ICC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Synapsin I (C-Term) is suitable for use in Western Blot and Immunocytochemistry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | M365 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Purification: | Antigen Affinity Purified |
| Dilution Range: | WB 1:1000ICC 1:50 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Syn1 |
| Gene ID: | 20964 |
| Uniprot ID: | SYN1_MOUSE |
| Immunogen Region: | C-Term |
| Specificity: | This antibody detects an 80 kDa* protein corresponding to the molecular mass of Synapsin I on SDS-PAGE immunoblots of adult mouse brain. |
| Immunogen: | Clone M365 was generated from a sequence corresponding to amino acids in the C-terminal region of mouse synapsin I. This sequence has high homology to human and rat synpasin I. |
| Function | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal. Also involved in the regulation of axon outgrowth and synaptogenesis. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxide functions at a presynaptic level. |
| Protein Name | Synapsin-1Synapsin I |
| Database Links | Reactome: R-MMU-181429Reactome: -MMU-212676 |
| Cellular Localisation | SynapseGolgi ApparatusPresynapseCytoplasmic VesicleSecretory VesicleSynaptic VesicleDissociates From Synaptic Vesicles And Redistributes Into The Axon During Action Potential FiringIn A Step That Precedes Fusion Of Vesicles With The Plasma MembraneReclusters To Presynapses After The Cessation Of Synaptic Activity |
| Alternative Antibody Names | Anti-Synapsin-1 antibodyAnti-Synapsin I antibodyAnti-Syn1 antibodyAnti-Syn-1 antibody |
Information sourced from Uniprot.org
