Anti-SV2C antibody (330-390 aa) (STJ96442)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the Internal region of human SV2C at the amino acid range 330-390
General Information
| Short Description | Rabbit polyclonal anti-Synaptic vesicle glycoprotein 2C (330-390 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC-P 1:100-300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SV2C |
| Gene ID | 22987 |
| Uniprot ID | SV2C_HUMAN |
| Immunogen | Synthesized peptide derived from the Internal region of human SV2C at the amino acid range 330-390 |
| Immunogen Region | 330-390 aa |
| Specificity | SV2C Polyclonal Antibody detects endogenous levels of SV2C protein. |
Additional Info
| Function | Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. (Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA).the toxin probably binds via extracellular loop 4. Recognition by BoNT/A relies on both protein-protein and protein-N-glycosylation.glycosylation of Asn-559 increases its affinity for BoNT/A. Also serves as a receptor for the closely related C.botulinum neurotoxin type A2.glycosylation is not essential but enhances the interaction. (Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD).note that type D does not usually infect humans. |
| Protein Name | Synaptic Vesicle Glycoprotein 2c |
| Database Links | Reactome: R-HSA-5250955Reactome: R-HSA-5250968Reactome: R-HSA-5250981 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneMulti-Pass Membrane ProteinEnriched In Small Synaptic Vesicles And Adrenal MicrosomesNot Present In Chromaffin GranulesAssociated With Both Insulin Granules And Synaptic-Like Microvesicles In Insulin-Secreting Cells Of The Pancreas |
| Alternative Antibody Names | Anti-Synaptic Vesicle Glycoprotein 2c antibodyAnti-SV2C antibodyAnti-KIAA1054 antibody |
Information sourced from Uniprot.org