• Immunohistochemical analysis of paraffin-embedded rat-brain, antibody was diluted at 1:100
  • Western blot analysis of extracts from Jurkat cells, using SV2C Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

Anti-SV2C antibody (330-390 aa) (STJ96442)

SKU:
STJ96442

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Synaptic vesicle glycoprotein 2C (330-390 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC-P 1:100-300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SV2C
Gene ID: 22987
Uniprot ID: SV2C_HUMAN
Immunogen Region: 330-390 aa
Specificity: SV2C Polyclonal Antibody detects endogenous levels of SV2C protein.
Immunogen: Synthesized peptide derived from the Internal region of human SV2C at the amino acid range 330-390
Function Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. (Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA).the toxin probably binds via extracellular loop 4. Recognition by BoNT/A relies on both protein-protein and protein-N-glycosylation.glycosylation of Asn-559 increases its affinity for BoNT/A. Also serves as a receptor for the closely related C.botulinum neurotoxin type A2.glycosylation is not essential but enhances the interaction. (Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD).note that type D does not usually infect humans.
Protein Name Synaptic Vesicle Glycoprotein 2c
Database Links Reactome: R-HSA-5250955
Reactome: R-HSA-5250968
Reactome: R-HSA-5250981
Cellular Localisation Cytoplasmic Vesicle
Secretory Vesicle
Synaptic Vesicle Membrane
Multi-Pass Membrane Protein
Enriched In Small Synaptic Vesicles And Adrenal Microsomes
Not Present In Chromaffin Granules
Associated With Both Insulin Granules And Synaptic-Like Microvesicles In Insulin-Secreting Cells Of The Pancreas
Alternative Antibody Names Anti-Synaptic Vesicle Glycoprotein 2c antibody
Anti-SV2C antibody
Anti-KIAA1054 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance