| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Small ubiquitin-related modifier 2 (45-95 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:5000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SUMO2 |
| Gene ID: | 6613 |
| Uniprot ID: | SUMO2_HUMAN |
| Immunogen Region: | 45-95 aa |
| Specificity: | This antibody detects endogenous levels of human SUMO2 |
| Immunogen: | Synthesized peptide derived from the human SUMO2 at the amino acid range 45-95 |
| Post Translational Modifications | Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4. Cleavage of precursor form by SENP1 or SENP2 is necessary for function. Monoubiquitinated N-terminally by UBE2W, which primes it for RNF4-dependent polyubiquitination by the UBE2V1-UBE2N heterodimer. |
| Function | Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX. |
| Protein Name | Small Ubiquitin-Related Modifier 2 Sumo-2 Hsmt3 Smt3 Homolog 2 Sumo-3 Sentrin-2 Ubiquitin-Like Protein Smt3b Smt3b |
| Database Links | Reactome: R-HSA-196791 Reactome: R-HSA-3065676 Reactome: R-HSA-3065678 Reactome: R-HSA-3065679 Reactome: R-HSA-3108214 Reactome: R-HSA-3232118 Reactome: R-HSA-3899300 Reactome: R-HSA-4085377 Reactome: R-HSA-4090294 Reactome: R-HSA-4551638 Reactome: R-HSA-4570464 Reactome: R-HSA-4615885 Reactome: R-HSA-5693607 Reactome: R-HSA-5696395 Reactome: R-HSA-9843940 |
| Cellular Localisation | Nucleus Pml Body |
| Alternative Antibody Names | Anti-Small Ubiquitin-Related Modifier 2 antibody Anti-Sumo-2 antibody Anti-Hsmt3 antibody Anti-Smt3 Homolog 2 antibody Anti-Sumo-3 antibody Anti-Sentrin-2 antibody Anti-Ubiquitin-Like Protein Smt3b antibody Anti-Smt3b antibody Anti-SUMO2 antibody Anti-SMT3B antibody Anti-SMT3H2 antibody |
Information sourced from Uniprot.org