| Tissue Specificity | Liver, lung, adrenal, brain, platelets and skin. |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine groupe. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones and 3,3'-diiodothyronin. Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil. Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis. May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system. |
| Protein Name | Sulfotransferase 1a1St1a1Aryl Sulfotransferase 1Hast1/Hast2Phenol Sulfotransferase 1Phenol-Sulfating Phenol Sulfotransferase 1P-Pst 1St1a3Thermostable Phenol SulfotransferaseTs-Pst |
| Database Links | Reactome: R-HSA-156584Reactome: R-HSA-9753281 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Sulfotransferase 1a1 antibodyAnti-St1a1 antibodyAnti-Aryl Sulfotransferase 1 antibodyAnti-Hast1/Hast2 antibodyAnti-Phenol Sulfotransferase 1 antibodyAnti-Phenol-Sulfating Phenol Sulfotransferase 1 antibodyAnti-P-Pst 1 antibodyAnti-St1a3 antibodyAnti-Thermostable Phenol Sulfotransferase antibodyAnti-Ts-Pst antibodyAnti-SULT1A1 antibodyAnti-STP antibodyAnti-STP1 antibodyAnti-OK antibodyAnti-SW-cl.88 antibody |
Information sourced from Uniprot.org
