| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-STXBP1 (295-594) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
STXBP1 |
| Gene ID: |
6812 |
| Uniprot ID: |
STXB1_HUMAN |
| Immunogen Region: |
295-594 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 295-594 of human STXBP1 (NP_001027392.1). |
| Immunogen Sequence: |
HIAEVSQEVTRSLKDFSSSK RMNTGEKTTMRDLSQMLKKM PQYQKELSKYSTHLHLAEDC MKHYQGTVDKLCRVEQDLAM GTDAEGEKIKDPMRAIVPIL LDANVSTYDKIRIILLYIFL KNGITEENLNKLIQHAQIPP EDSEIITNMAHLGVPIVTDS TLRRRSKPERKERISEQTYQ LSRWTPIIKDIMEDTIEDKL DTKHYPYISTRSSASFSTTA VSARYGHWHKNKAPGEYRS |
| Tissue Specificity | Brain and spinal cord. Highly enriched in axons. |
| Function | Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synapic membranes. May play a role in determining the specificity of intracellular fusion reactions. |
| Protein Name | Syntaxin-Binding Protein 1Munc18-1N-Sec1Protein Unc-18 Homolog 1Unc18-1Protein Unc-18 Homolog AUnc-18aP67 |
| Database Links | Reactome: R-HSA-181429 P61764-1Reactome: R-HSA-181430 P61764-1Reactome: R-HSA-210500 P61764-1Reactome: R-HSA-212676 P61764-1Reactome: R-HSA-264642 P61764-1Reactome: R-HSA-422356Reactome: R-HSA-6794361Reactome: R-HSA-888590 P61764-1 |
| Cellular Localisation | CytoplasmCytosolMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Syntaxin-Binding Protein 1 antibodyAnti-Munc18-1 antibodyAnti-N-Sec1 antibodyAnti-Protein Unc-18 Homolog 1 antibodyAnti-Unc18-1 antibodyAnti-Protein Unc-18 Homolog A antibodyAnti-Unc-18a antibodyAnti-P67 antibodyAnti-STXBP1 antibodyAnti-UNC18A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
