| Post Translational Modifications | Phosphorylated at Tyr-157 probably by ABL1. Dephosphorylation by PTPN2.regulates exit from the endoplasmic reticulum. (Microbial infection) Cleaved by the L.pneumophila serine protease Lpg1137, impairing endoplasmic reticulum-mitochondria communication, leading to inhibit autophagy. |
| Function | SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi. |
| Protein Name | Syntaxin-17 |
| Database Links | Reactome: R-HSA-204005 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinSmooth Endoplasmic Reticulum MembraneEndoplasmic Reticulum-Golgi Intermediate Compartment MembraneCytoplasmic VesicleAutophagosome MembraneCopii-Coated Vesicle MembraneCytoplasmCytosolMitochondrion MembraneAutolysosome MembraneHas A Hairpin-Like Insertion Into MembranesLocalizes To The Completed Autophagosome Membrane Upon Cell StarvationColocalized With Rab39a And Rab39b In Autolysosomes In Autophagy-Induced Conditions |
| Alternative Antibody Names | Anti-Syntaxin-17 antibodyAnti-STX17 antibody |
Information sourced from Uniprot.org
