Anti-STX17 antibody (1-130) (STJ11102869)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal STX17 (1-130) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | STX17 |
| Gene ID | 55014 |
| Uniprot ID | STX17_HUMAN |
| Immunogen Region | 1-130 |
| Immunogen Sequence | MSEDEEKVKLRRLEPAIQKF IKIVIPTDLERLRKHQINIE KYQRCRIWDKLHEEHINAGR TVQQLRSNIREIEKLCLKVR KDDLVLLKRMIDPVKEEASA ATAEFLQLHLESVEELKKQF NDEETLLQPP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human STX17 (NP_060389.2). |
Additional Info
| Post Translational Modifications | Phosphorylated at Tyr-157 probably by ABL1. Dephosphorylation by PTPN2.regulates exit from the endoplasmic reticulum. (Microbial infection) Cleaved by the L.pneumophila serine protease Lpg1137, impairing endoplasmic reticulum-mitochondria communication, leading to inhibit autophagy. |
| Function | SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi. |
| Protein Name | Syntaxin-17 |
| Database Links | Reactome: R-HSA-204005 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinSmooth Endoplasmic Reticulum MembraneEndoplasmic Reticulum-Golgi Intermediate Compartment MembraneCytoplasmic VesicleAutophagosome MembraneCopii-Coated Vesicle MembraneCytoplasmCytosolMitochondrion MembraneAutolysosome MembraneHas A Hairpin-Like Insertion Into MembranesLocalizes To The Completed Autophagosome Membrane Upon Cell StarvationColocalized With Rab39a And Rab39b In Autolysosomes In Autophagy-Induced Conditions |
| Alternative Antibody Names | Anti-Syntaxin-17 antibodyAnti-STX17 antibody |
Information sourced from Uniprot.org