| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-STRAP (1-350) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
STRAP |
| Gene ID: |
11171 |
| Uniprot ID: |
STRAP_HUMAN |
| Immunogen Region: |
1-350 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human STRAP (NP_009109.3). |
| Immunogen Sequence: |
MAMRQTPLTCSGHTRPVVDL AFSGITPYGYFLISACKDGK PMLRQGDTGDWIGTFLGHKG AVWGATLNKDATKAATAAAD FTAKVWDAVSGDELMTLAHK HIVKTVDFTQDSNYLLTGGQ DKLLRIYDLNKPEAEPKEIS GHTSGIKKALWCSEDKQILS ADDKTVRLWDHATMTEVKSL NFNMSVSSMEYIPEGEILVI TYGRSIAFHSAVSLDPIKSF EAPATINSASLHPEKEFLV |
| Function | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. |
| Protein Name | Serine-Threonine Kinase Receptor-Associated ProteinMap Activator With Wd RepeatsUnr-Interacting ProteinWd-40 Repeat Protein Pt-Wd |
| Database Links | Reactome: R-HSA-2173788 |
| Cellular Localisation | CytoplasmNucleusLocalized Predominantly In The Cytoplasm But Also Found In The Nucleus |
| Alternative Antibody Names | Anti-Serine-Threonine Kinase Receptor-Associated Protein antibodyAnti-Map Activator With Wd Repeats antibodyAnti-Unr-Interacting Protein antibodyAnti-Wd-40 Repeat Protein Pt-Wd antibodyAnti-STRAP antibodyAnti-MAWD antibodyAnti-UNRIP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
