| Function | Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER. SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts by interacting with STIM1, promoting STIM1 conformational switch. Involved in STIM1 relocalization to ER-PM junctions. Contributes to the maintenance and reorganization of store-dependent ER-PM junctions. |
| Protein Name | Store-Operated Calcium Entry Regulator StimateStim-Activating Enhancer Encoded By Tmem110Transmembrane Protein 110 |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinColocalizes With Stim1 At Er-Plasma Membrane (Er-Pm) JunctionsAlso Called Cortical Endoplasmic Reticulum (Er)In Store-Depleted Calcium CellsMay Translocate To Er-Pm Junctions In A Stim1-Dependent Manner In Store-Depleted Cells (Probable) |
| Alternative Antibody Names | Anti-Store-Operated Calcium Entry Regulator Stimate antibodyAnti-Stim-Activating Enhancer Encoded By Tmem110 antibodyAnti-Transmembrane Protein 110 antibodyAnti-STIMATE antibodyAnti-TMEM110 antibody |
Information sourced from Uniprot.org
