| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Store-operated calcium entry regulator STIMATE (220-270 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | STIMATE |
| Gene ID: | 375346 |
| Uniprot ID: | STIMA_HUMAN |
| Immunogen Region: | 220-270 aa |
| Specificity: | This antibody detects endogenous levels of human TM110 |
| Immunogen: | Synthesized peptide derived from the human TM110 at the amino acid range 220-270 |
| Function | Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER. SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts by interacting with STIM1, promoting STIM1 conformational switch. Involved in STIM1 relocalization to ER-PM junctions. Contributes to the maintenance and reorganization of store-dependent ER-PM junctions. |
| Protein Name | Store-Operated Calcium Entry Regulator Stimate Stim-Activating Enhancer Encoded By Tmem110 Transmembrane Protein 110 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Colocalizes With Stim1 At Er-Plasma Membrane (Er-Pm) Junctions Also Called Cortical Endoplasmic Reticulum (Er) In Store-Depleted Calcium Cells May Translocate To Er-Pm Junctions In A Stim1-Dependent Manner In Store-Depleted Cells (Probable) |
| Alternative Antibody Names | Anti-Store-Operated Calcium Entry Regulator Stimate antibody Anti-Stim-Activating Enhancer Encoded By Tmem110 antibody Anti-Transmembrane Protein 110 antibody Anti-STIMATE antibody Anti-TMEM110 antibody |
Information sourced from Uniprot.org