Anti-STIMATE antibody (220-270 aa) (STJ197567)

SKU:
STJ197567
£48.00 - £252.00
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Store-operated calcium entry regulator STIMATE (220-270 aa) is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: STIMATE
Gene ID: 375346
Uniprot ID: STIMA_HUMAN
Immunogen Region: 220-270 aa
Specificity: This antibody detects endogenous levels of human TM110
Immunogen: Synthesized peptide derived from the human TM110 at the amino acid range 220-270
Function Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER. SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts by interacting with STIM1, promoting STIM1 conformational switch. Involved in STIM1 relocalization to ER-PM junctions. Contributes to the maintenance and reorganization of store-dependent ER-PM junctions.
Protein Name Store-Operated Calcium Entry Regulator Stimate
Stim-Activating Enhancer Encoded By Tmem110
Transmembrane Protein 110
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Colocalizes With Stim1 At Er-Plasma Membrane (Er-Pm) Junctions
Also Called Cortical Endoplasmic Reticulum (Er)
In Store-Depleted Calcium Cells
May Translocate To Er-Pm Junctions In A Stim1-Dependent Manner In Store-Depleted Cells (Probable)
Alternative Antibody Names Anti-Store-Operated Calcium Entry Regulator Stimate antibody
Anti-Stim-Activating Enhancer Encoded By Tmem110 antibody
Anti-Transmembrane Protein 110 antibody
Anti-STIMATE antibody
Anti-TMEM110 antibody

Information sourced from Uniprot.org

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