| Host: | Goat |
| Applications: | Pep-ELISA/WB/FC |
| Reactivity: | Human/Mouse/Dog/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-STAM2 (Internal) is suitable for use in ELISA, Western Blot and Flow Cytometry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:8000.WB: Approx 70kDa band observed in Human Spleen lysates and in preliminary testing of HeLa cell lysate (calculated MW of 58.2kDa according to NP_005834.3). This molecular weight is routinely |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | STAM2 |
| Gene ID: | 10254 |
| Uniprot ID: | STAM2_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_005834.3 |
| Specificity: | No cross-reaction expected with STAM1. |
| Immunogen Sequence: | QSIDPTDSKPDSQD |
| Post Translational Modifications | Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF. |
| Function | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. |
| Protein Name | Signal Transducing Adapter Molecule 2Stam-2Hrs-Binding Protein |
| Database Links | Reactome: R-HSA-182971Reactome: R-HSA-5689880Reactome: R-HSA-6807004Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8875360Reactome: R-HSA-9013420Reactome: R-HSA-917729 |
| Cellular Localisation | CytoplasmEarly Endosome MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Signal Transducing Adapter Molecule 2 antibodyAnti-Stam-2 antibodyAnti-Hrs-Binding Protein antibodyAnti-STAM2 antibodyAnti-HBP antibody |
Information sourced from Uniprot.org