• Immunofluorescence analysis of U-2 OS cells using STAM2 antibody (STJ29138) at dilution of 1:100. Blue: DAPI for nuclear staining.
  • Immunofluorescence analysis of L929 cells using STAM2 antibody (STJ29138) at dilution of 1:100. Blue: DAPI for nuclear staining.
  • Immunofluorescence analysis of C6 cells using STAM2 antibody (STJ29138) at dilution of 1:100. Blue: DAPI for nuclear staining.
  • Western blot analysis of extracts of various cell lines, using STAM2 antibody (STJ29138) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.

Anti-STAM2 antibody (376-525) (STJ29138)

SKU:
STJ29138

£112.50 - £522.50
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Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-STAM2 (376-525) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: STAM2
Gene ID: 10254
Uniprot ID: STAM2_HUMAN
Immunogen Region: 376-525
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 376-525 of human STAM2 (NP_005834.4).
Immunogen Sequence: KLHPPAHYPPASSGVPMQTY PVQSHGGNYMGQSIHQVTVA QSYSLGPDQIGPLRSLPPNV NSSVTAQPAQTSYLSTGQDT VSNPTYMNQNSNLQSATGTT AYTQQMGMSVDMSSYQNTTS NLPQLAGFPVTVPAHPVAQQ HTNYHQQPLL
Tissue Specificity Ubiquitously expressed.
Post Translational Modifications Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF.
Function Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
Protein Name Signal Transducing Adapter Molecule 2
Stam-2
Hrs-Binding Protein
Database Links Reactome: R-HSA-182971
Reactome: R-HSA-5689880
Reactome: R-HSA-6807004
Reactome: R-HSA-8856825
Reactome: R-HSA-8856828
Reactome: R-HSA-8875360
Reactome: R-HSA-9013420
Reactome: R-HSA-917729
Cellular Localisation Cytoplasm
Early Endosome Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Alternative Antibody Names Anti-Signal Transducing Adapter Molecule 2 antibody
Anti-Stam-2 antibody
Anti-Hrs-Binding Protein antibody
Anti-STAM2 antibody
Anti-HBP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance