Anti-STAM2 antibody (161-210 aa) (STJ95800)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human STAM2 at the amino acid range 161-210
General Information
| Short Description | Rabbit polyclonal anti-Signal transducing adapter molecule 2 (161-210 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | STAM2 |
| Gene ID | 10254 |
| Uniprot ID | STAM2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human STAM2 at the amino acid range 161-210 |
| Immunogen Region | 161-210 aa |
| Specificity | STAM2 Polyclonal Antibody detects endogenous levels of STAM2 protein. |
Additional Info
| Post Translational Modifications | Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF. |
| Function | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. |
| Protein Name | Signal Transducing Adapter Molecule 2Stam-2Hrs-Binding Protein |
| Database Links | Reactome: R-HSA-182971Reactome: R-HSA-5689880Reactome: R-HSA-6807004Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8875360Reactome: R-HSA-9013420Reactome: R-HSA-917729 |
| Cellular Localisation | CytoplasmEarly Endosome MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Signal Transducing Adapter Molecule 2 antibodyAnti-Stam-2 antibodyAnti-Hrs-Binding Protein antibodyAnti-STAM2 antibodyAnti-HBP antibody |
Information sourced from Uniprot.org