| Tissue Specificity | Ubiquitous. High expression in brain, skeletal muscle, placenta, and testis. mRNA widely distributed in human brain, but slightly elevated expression was observed in the cerebral cortex, temporal lobe, and putamen. |
| Post Translational Modifications | N-glycosylated. |
| Function | Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the non-reducing terminal galactose (Gal) of glycosphingolipids forming gangliosides (important molecules involved in the regulation of multiple cellular processes, including cell proliferation and differentiation, apoptosis, embryogenesis, development, and oncogenesis). Mainly involved in the biosynthesis of ganglioside GM3 but can also use different glycolipids as substrate acceptors such as D-galactosylceramide (GalCer), asialo-GM2 (GA2) and asialo-GM1 (GA1), although less preferentially than beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer (LacCer). |
| Protein Name | Lactosylceramide Alpha-2 -3-SialyltransferaseCmp-Neuac -Lactosylceramide Alpha-2 -3-SialyltransferaseGm3 SynthaseGanglioside Gm3 SynthaseSt3gal VSt3galvSialyltransferase 9 |
| Database Links | Reactome: R-HSA-4085001Reactome: R-HSA-9840309 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Lactosylceramide Alpha-2 -3-Sialyltransferase antibodyAnti-Cmp-Neuac -Lactosylceramide Alpha-2 -3-Sialyltransferase antibodyAnti-Gm3 Synthase antibodyAnti-Ganglioside Gm3 Synthase antibodyAnti-St3gal V antibodyAnti-St3galv antibodyAnti-Sialyltransferase 9 antibodyAnti-ST3GAL5 antibodyAnti-SIAT9 antibodyAnti-UNQ2510 antibodyAnti-PRO5998 antibody |
Information sourced from Uniprot.org
