| Host: |
Rabbit |
| Applications: |
WB/ICC/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Slingshot-1L (C-Term) is suitable for use in Western Blot, Immunocytochemistry and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Purification: |
Antigen Affinity Purified |
| Dilution Range: |
WB 1:1000IHC 1:100ICC 1:250IP |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SSH1 |
| Gene ID: |
54434 |
| Uniprot ID: |
SSH1_HUMAN |
| Immunogen Region: |
C-Term |
| Specificity: |
The antibody detects a 150 kDa* protein corresponding to the molecular mass of SSH1L on SDS-PAGE immunoblots of PC12 cells. |
| Immunogen: |
A synthetic peptide (coupled to KLH) corresponding to amino acid residues in the C-terminal region of human SSH1L. This sequence has 100% homology with similar regions of mouse and bovine SSH1L, and has low homology to SSH2L and SSH3L. |
| Function | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. |
| Protein Name | Protein Phosphatase Slingshot Homolog 1Ssh-Like Protein 1Ssh-1lHssh-1l |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionLamellipodiumCleavage FurrowMidbodyAlso Recruited To Actin Rich Membrane Protrusions Such As LamellipodiaWhich May Allow Local Control Of Actin Dynamics At Sites Of Cell LocomotionAlso Localized To The Cleavage Furrow And The Midbody During Cytokinesis |
| Alternative Antibody Names | Anti-Protein Phosphatase Slingshot Homolog 1 antibodyAnti-Ssh-Like Protein 1 antibodyAnti-Ssh-1l antibodyAnti-Hssh-1l antibodyAnti-SSH1 antibodyAnti-KIAA1298 antibodyAnti-SSH1L antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
