| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/IP/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:100-1:500IF/ICC:1:50-1:200IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your speci |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SSB |
| Gene ID: | 6741 |
| Uniprot ID: | LA_HUMAN |
| Immunogen Region: | 166-408 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 166-408 of human SSB (NP_003133.1). |
| Immunogen Sequence: | KFVETPGQKYKETDLLILFK DDYFAKKNEERKQNKVEAKL RAKQEQEAKQKLEEDAEMKS LEEKIGCLLKFSGDLDDQTC REDLHILFSNHGEIKWIDFV RGAKEGIILFKEKAKEALGK AKDANNGNLQLRNKEVTWEV LEGEVEKEALKKIIEDQQES LNKWKSKGRRFKGKGKGNKA AQPGSGKGKVQFQGKKTKFA SDDEHDEHDENGATGPVKRA REETDKEEPASKQQKTENG |
| Post Translational Modifications | Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein. The N-terminus is blocked. |
| Function | Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation. |
| Protein Name | Lupus La ProteinLa AutoantigenLa RibonucleoproteinSjoegren Syndrome Type B AntigenSs-B |
| Database Links | Reactome: R-HSA-73980Reactome: R-HSA-749476 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lupus La Protein antibodyAnti-La Autoantigen antibodyAnti-La Ribonucleoprotein antibodyAnti-Sjoegren Syndrome Type B Antigen antibodyAnti-Ss-B antibodyAnti-SSB antibody |
Information sourced from Uniprot.org